Rabbit Hole

[Auburn93]

I enjoyed the Netflix series Rabbit Hole, but wanted to give you an idea of how I go down the rabbit hole when researching.

I hear that males are almost twice as likely to die from COVID than females up until menopause, so I research the differences between males and females pre and post menopause.

Research shows that females have more fucosylated IgG than males up until menopause. and then their levels become equal.

I research fucosylated IgG immune response in COVID and it shows the difference in having fucosylated IgG (less COVID severity) and not having enough fucosylated IgG (COVID severity).

During the search, I read how certain pathogens, like Candida, deplete fucose from our GI tract and weaken our immunity. People with more intestinal Candida may have less available fucose in their GI mucosa to protect them and people with less fucose have higher incidence of colitis. It has to do with intestinal tryptophan metabolism and microbiota regulation. This could lead to more research on mucosal barriers, E coli tryptophan production, and an entirely different rabbit hole to go down being E coli is a gram negative anaerobe and they flourish with higher nitrogen environments. It is never ending.

 

[Illubrinatti]

K.

Is any of that covered in the movie?

 

[Auburn93]

K.

Is any of that covered in the movie?

No, but the series is worth a watch.

 

[Auburn73]

I enjoyed the Netflix series Rabbit Hole, but wanted to give you an idea of how I go down the rabbit hole when researching.

I hear that males are almost twice as likely to die from COVID than females up until menopause, so I research the differences between males and females pre and post menopause.

Research shows that females have more fucosylated IgG than males up until menopause. and then their levels become equal.

I research fucosylated IgG immune response in COVID and it shows the difference in having fucosylated IgG (less COVID severity) and not having enough fucosylated IgG (COVID severity).

During the search, I read how certain pathogens, like Candida, deplete fucose from our GI tract and weaken our immunity. People with more intestinal Candida may have less available fucose in their GI mucosa to protect them and people with less fucose have higher incidence of colitis. It has to do with intestinal tryptophan metabolism and microbiota regulation. This could lead to more research on mucosal barriers, E coli tryptophan production, and an entirely different rabbit hole to go down being E coli is a gram negative anaerobe and they flourish with higher nitrogen environments. It is never ending.

Sooo….. SHORT answer…… what foods, vitamin,and/or supplements increase “ focosylated IgG? In lay-person terms…..

WDE

 

[au4life_rz]

I enjoyed the Netflix series Rabbit Hole, but wanted to give you an idea of how I go down the rabbit hole when researching.

I hear that males are almost twice as likely to die from COVID than females up until menopause, so I research the differences between males and females pre and post menopause.

Research shows that females have more fucosylated IgG than males up until menopause. and then their levels become equal.

I research fucosylated IgG immune response in COVID and it shows the difference in having fucosylated IgG (less COVID severity) and not having enough fucosylated IgG (COVID severity).

During the search, I read how certain pathogens, like Candida, deplete fucose from our GI tract and weaken our immunity. People with more intestinal Candida may have less available fucose in their GI mucosa to protect them and people with less fucose have higher incidence of colitis. It has to do with intestinal tryptophan metabolism and microbiota regulation. This could lead to more research on mucosal barriers, E coli tryptophan production, and an entirely different rabbit hole to go down being E coli is a gram negative anaerobe and they flourish with higher nitrogen environments. It is never ending.

Good rabbit-holing Auburn93. The connections are there. They are just waiting to be discovered.

 

[fntiger]

Rabbit Hole isn’t on Netflix, is it?

 

[Auburn93]

Sooo….. SHORT answer…… what foods, vitamin,and/or supplements increase “ focosylated IgG? In lay-person terms…..

WDE

Eat fruit, apples, avocadoes, nuts, mushrooms, and other foods that aren't overly processed. Avoid acidic drinks and processed foods. The rule of thumb is to eat foods with less than 5 ingredients.

 

[Creed_Killer]

Eat fruit, apples, avocadoes, nuts, mushrooms, and other foods that aren't overly processed. Avoid acidic drinks and processed foods. The rule of thumb is to eat foods with less than 5 ingredients.

How real is brain fog and what is it exactly? I feel like I still have brain fog from COVID two years ago.

 

[Auburn93]

Rabbit Hole isn’t on Netflix, is it?

Either that or Prime.

 

[MCTIGgER IV]

Eat fruit, apples, avocadoes, nuts, mushrooms, and other foods that aren't overly processed. Avoid acidic drinks and processed foods. The rule of thumb is to eat foods with less than 5 ingredients.

3 things I did and went from having the worst immune system in my family to the best......

1. Try not to eat anything with a barcode (mainly a function of avoiding a xanthan gum allergy when I didn't know it was xanthan gum but woah at what a difference to health it made.

2. Take a supergreen supplement with digestive enzymes and probiotics every day. I use amazing grass.

3. Drink 3 liters of water every day with a pinch of Himalayan pink salt and a teaspoon of Bragg's apple cider vinegar added to each liter.

Next step is to cut coffee.

 

[Auburn93]

How real is brain fog and what is it exactly? I feel like I still have brain fog from COVID two years ago.

Brain fog is real and it occurs in several health conditions. I propose the mechanism as follows. This is not found in the literature, this is what I have determined after years of research on the subject. The cause of brain fog is a pH imbalance in the GI tract. My proposed mechanism is a bacterial ratio issue between several phyla in the GI tract. Ammonia in the GI tract increases because it is produced by too many gram negative anaerobes (some by gram positive). This pH slows the growth of certain other bacteria. Ammonia is absorbed through the portal duct (approx. 40 g) directly into the liver in an attempt to lower intralumenal pH. It eventually isn't metabolized efficiently enough and it passes into the brain via the blood brain barrier into astrocytes. To decrease brain fog, reduce the gram negative anaerobes in the GI tract. Do this by eating less nitrogen and sulfur laden foods. This will alter the pH is a favorable way and reduce brain fog.

 

[mooseau]

Do probiotics help with that PH balance @Auburn93?

 

[Daddy4?]

Brain fog is real and it occurs in several health conditions. I propose the mechanism as follows. This is not found in the literature, this is what I have determined after years of research on the subject. The cause of brain fog is a pH imbalance in the GI tract. My proposed mechanism is a bacterial ratio issue between several phyla in the GI tract. Ammonia in the GI tract increases because it is produced by too many gram negative anaerobes (some by gram positive). This pH slows the growth of certain other bacteria. Ammonia is absorbed through the portal duct (approx. 40 g) directly into the liver in an attempt to lower intralumenal pH. It eventually isn't metabolized efficiently enough and it passes into the brain via the blood brain barrier into astrocytes. To decrease brain fog, reduce the gram negative anaerobes in the GI tract. Do this by eating less nitrogen and sulfur laden foods. This will alter the pH is a favorable way and reduce brain fog.

You’re never going to die, are you?

 

[LexTiger]

Brain fog is real and it occurs in several health conditions. I propose the mechanism as follows. This is not found in the literature, this is what I have determined after years of research on the subject. The cause of brain fog is a pH imbalance in the GI tract. My proposed mechanism is a bacterial ratio issue between several phyla in the GI tract. Ammonia in the GI tract increases because it is produced by too many gram negative anaerobes (some by gram positive). This pH slows the growth of certain other bacteria. Ammonia is absorbed through the portal duct (approx. 40 g) directly into the liver in an attempt to lower intralumenal pH. It eventually isn't metabolized efficiently enough and it passes into the brain via the blood brain barrier into astrocytes. To decrease brain fog, reduce the gram negative anaerobes in the GI tract. Do this by eating less nitrogen and sulfur laden foods. This will alter the pH is a favorable way and reduce brain fog.

This is exactly what I was going to post in response. Great minds think alike!

 

[Auburn93]

Do probiotics help with that PH balance @Auburn93?

Most of the time no, but sometimes they can help. Many people have high fungal loads and probiotics like Align can help. It basically puts in good fungi(Saccharomyces) to help overpower the bad fungi (Candida). The main determinant of GI pH is the food we eat. Over time, the increased acidity of what we eat adversely affects our GI bacterial ratios.

You’re never going to die, are you?

Yes, probably before you. I honestly believe I would already be dead if I hadn't learned how to live with my condition.

 

[Creed_Killer]

Brain fog is real and it occurs in several health conditions. I propose the mechanism as follows. This is not found in the literature, this is what I have determined after years of research on the subject. The cause of brain fog is a pH imbalance in the GI tract. My proposed mechanism is a bacterial ratio issue between several phyla in the GI tract. Ammonia in the GI tract increases because it is produced by too many gram negative anaerobes (some by gram positive). This pH slows the growth of certain other bacteria. Ammonia is absorbed through the portal duct (approx. 40 g) directly into the liver in an attempt to lower intralumenal pH. It eventually isn't metabolized efficiently enough and it passes into the brain via the blood brain barrier into astrocytes. To decrease brain fog, reduce the gram negative anaerobes in the GI tract. Do this by eating less nitrogen and sulfur laden foods. This will alter the pH is a favorable way and reduce brain fog.

Interesting. It seems anyone on a low carb/keto diet would possibly have this issue.

 

[au4life_rz]

Most of the time no, but sometimes they can help. Many people have high fungal loads and probiotics like Align can help. It basically puts in good fungi(Saccharomyces) to help overpower the bad fungi (Candida). The main determinant of GI pH is the food we eat. Over time, the increased acidity of what we eat adversely affects our GI bacterial ratios.

Yes, probably before you. I honestly believe I would already be dead if I hadn't learned how to live with my condition.

I've tried to manage my GI, not through probiotics, but by simply eating as many super foods and vegetables as close to their natural state as possible. Legumes, Spinach, sweet potatoes, raw cruciferous veggies such as cabbage, Kale, broccoli et. al. Lots of garlic in all of my cooked foods.

If we eat high fiber, healthy foods, it seems that the GI tract will eventually take care of itself in regards to the ratios of good bacteria to bad, (and all of the tons of other health benefits that come along with it). I've used probiotics from time to time, but I don't want to depend on them.

 

[Auburn93]

Interesting. It seems anyone on a low carb/keto diet would possibly have this issue.

They can and often have it initially, but they are able to adjust where we high fungal load people don't do as well.

 

[TridentAU]

Rabbit Hole isn’t on Netflix, is it?

Paramount+

 

[Jesus Beaver]

Eat fruit, apples, avocadoes, nuts, mushrooms, and other foods that aren't overly processed. Avoid acidic drinks and processed foods. The rule of thumb is to eat foods with less than 5 ingredients.

That’s interesting. My dad is 87 and had a heart attack last year (2022) then had covid twice this year. First time put him in the hospital with pneumonia. Never was on a ventilator or anything like that but still a bit of a scare because it took forever to get rid of the pneumonia. He’s very fit and active (plays pickle ball non stop) and eats very healthy- lots of fruit and nuts.. I always tell him he eats rabbit food lol. But that is his main diet with maybe a protein like fish or chicken for dinner or lunch. Besides his little sweet tooth he’s pretty healthy.

 

[Aliens]

Generally, lower body fat yields better outcomes vs any diseases.

 

[BeatBama60]

I enjoyed the Netflix series Rabbit Hole, but wanted to give you an idea of how I go down the rabbit hole when researching.

I hear that males are almost twice as likely to die from COVID than females up until menopause, so I research the differences between males and females pre and post menopause.

Research shows that females have more fucosylated IgG than males up until menopause. and then their levels become equal.

I research fucosylated IgG immune response in COVID and it shows the difference in having fucosylated IgG (less COVID severity) and not having enough fucosylated IgG (COVID severity).

During the search, I read how certain pathogens, like Candida, deplete fucose from our GI tract and weaken our immunity. People with more intestinal Candida may have less available fucose in their GI mucosa to protect them and people with less fucose have higher incidence of colitis. It has to do with intestinal tryptophan metabolism and microbiota regulation. This could lead to more research on mucosal barriers, E coli tryptophan production, and an entirely different rabbit hole to go down being E coli is a gram negative anaerobe and they flourish with higher nitrogen environments. It is never ending.

Came here to post this?

 

[Auburn93]

If we eat high fiber, healthy foods, it seems that the GI tract will eventually take care of itself in regards to the ratios of good bacteria to bad, (and all of the tons of other health benefits that come along with it). I've used probiotics from time to time, but I don't want to depend on them.

Normally, you are correct about our GI tract taking care of itself. Problems do occur when individuals have pathogens that alter intestinal milieu and the pH of what they eat isn't the main determinant for their bacterial floral composition. For instance, it doesn't matter how many grams of fiber I eat, I can only harbor enough bacteria to break down about 50 g of fiber per day. I just don't have enough intestinal surface area to break down more fiber. Anything over 50 g of fiber increases gas production. Many people don't have enough intestinal surface area because their pH drives their Lactobacillus into more mucin production which basically makes it inactive. That's one of its survival mechanisms to cope with altered pH but the extra mucin takes up about 5 times as much surface area when it is inactive. This limits surface area and cilia availability.

 

[jdAU08]

OP is insufferable

 

[Auburn93]

OP is insufferable

I would be honored if you would block me.

 

[tugmac]

Rabbit Hole isn’t on Netflix, is it?

Paramount+

 

[jdAU08]

I would be honored if you would block me.

Done. Go post on Facebook

 

[JLEAGLE07]

I use to partake in the threads when people were talking shit to OP about this stuff. I would like to apologize to @Auburn93 for participating years ago in that. I firmly believe that gut microbiome is one of the most important factors in long term healthy living. Outside of genetics, it may be the most important and even some genetic things can be worked around to help.

We, as in humanity, need to really revolutionize and develop a field of medical GUT microbiology, genetics, pathology, diagnostics, and treatment. This could cure or treat a lot of disease and increase life expectancy. We have MDs that specialize in cardiology, gastroenterology (not the same as I am talking about), radiology, neurology, etc but we really need a field where medical schools and even PHD programs offer this area of study. And I’m not talking about a course or two I’m talking about someone coming out of medical school and enters the field or research into this or is a specialist in GUT medical microbiology, genetics, path etc. jmo

 

[Jay G. Tate]

I enjoyed the Netflix series Rabbit Hole, but wanted to give you an idea of how I go down the rabbit hole when researching.

I hear that males are almost twice as likely to die from COVID than females up until menopause, so I research the differences between males and females pre and post menopause.

Research shows that females have more fucosylated IgG than males up until menopause. and then their levels become equal.

I research fucosylated IgG immune response in COVID and it shows the difference in having fucosylated IgG (less COVID severity) and not having enough fucosylated IgG (COVID severity).

During the search, I read how certain pathogens, like Candida, deplete fucose from our GI tract and weaken our immunity. People with more intestinal Candida may have less available fucose in their GI mucosa to protect them and people with less fucose have higher incidence of colitis. It has to do with intestinal tryptophan metabolism and microbiota regulation. This could lead to more research on mucosal barriers, E coli tryptophan production, and an entirely different rabbit hole to go down being E coli is a gram negative anaerobe and they flourish with higher nitrogen environments. It is never ending.

My guy, I'm going to go ahead and give you a fuggin timeout. You put this on the wrong board on purpose and you're still beating this dead horse and, man, we're all just tired of your schtick. Covid? In May 2023? Just go somewhere else and be this guy. Seriously. Stop. Stop. Stop. Stop. Stop. Stop.