I stated awhile back that if I had COVID, I'd take 30mg of Melatonin three times a day. I didn't just make that up, I had read a lot about what Melatonin does inside the cell and what high doses can do to viral replication.
Flash forward to now, "a new peer-reviewed study published by a team of researchers from the Gladstone Institute of Data Science and Biotechnology (USA) discovered that heightened infectiveness and transmissibility of variants are caused not by mutations in the spike protein but the structural nucleocapsid or N protein." Basically, the N protein was the single most important factor in increasing the infectivity of the Delta variant. Why is this important? Because right now, all products targeting the virus re based off of the spike protein. The only thing we know of that can affect the N protein is Melatonin.
In order for viruses to replicate, they must form biomolecular condensates inside our cells. Melatonin directly regulates the phase separation of biomolecular condensates inside our cells. For the virus to replicate, it has to hijack our normal phase separation. Melatonin directly regulates our processes of phase separation and may be able to cause the disassembly of those viral condensates formed by N proteins.
Everyone won't be able to handle high doses of Melatonin. If you have mitochondrial issues or other viral infections, you may not be able to handle the increased oxidative stress. This could be why some "normal" people don't fare well when getting COVID. They have other viral infections and their Melatonin levels aren't sufficient enough to prevent the increase in oxidative stress which can lead to multiple systemic issues.
Flash forward to now, "a new peer-reviewed study published by a team of researchers from the Gladstone Institute of Data Science and Biotechnology (USA) discovered that heightened infectiveness and transmissibility of variants are caused not by mutations in the spike protein but the structural nucleocapsid or N protein." Basically, the N protein was the single most important factor in increasing the infectivity of the Delta variant. Why is this important? Because right now, all products targeting the virus re based off of the spike protein. The only thing we know of that can affect the N protein is Melatonin.
In order for viruses to replicate, they must form biomolecular condensates inside our cells. Melatonin directly regulates the phase separation of biomolecular condensates inside our cells. For the virus to replicate, it has to hijack our normal phase separation. Melatonin directly regulates our processes of phase separation and may be able to cause the disassembly of those viral condensates formed by N proteins.
Everyone won't be able to handle high doses of Melatonin. If you have mitochondrial issues or other viral infections, you may not be able to handle the increased oxidative stress. This could be why some "normal" people don't fare well when getting COVID. They have other viral infections and their Melatonin levels aren't sufficient enough to prevent the increase in oxidative stress which can lead to multiple systemic issues.
